It wil take place in Medford at KOBI TV and will also be streamed on the web starting at 7 P.M.
The two candidates have gone round and round about different debates, but the two failed to come to terms on any other debate except the one Tuesday night in Medford.
Senator Merkley is seeking his first reelection and his Republcian challenger Monica Wehby, who is a Portland pediatric neurosurgeon and has never run for public office before.