(Flushing, NY)  --  There are some notable faces missing from this year's US Open tournament.  For the first time since 2000, a Grand Slam will not feature Roger Federer, Rafael Nadal or Serena Williams as all three are sidelined with injuries.  On the men's side, that may give Novak Djokovic a chance to complete the first men's calendar-year Grand Slam since Rod Laver did it in 1969.  Daniil Medvedev and Stefanos Tsitsipas round out the top-three seeds in the draw.  On the women's side, defending US Open champ Naomi Osaka is competing in her first major since the French Open earlier this year. She'll have to dethrone top-seeded Ashleigh Barty to take her third US Open title.