(New Orleans, LA) -- The Saints are picking up a big win over the defending champs. P.J. Williams returned an interception for a touchdown to seal the victory as the Saints defeated the Buccaneers 36-27 in New Orleans. Trevor Siemian threw a touchdown in place of Jameis Winston, who left the game with a potentially "significant" knee injury. Tom Brady threw four touchdowns and two interceptions in the loss for the Buccaneers.