(Nashville, TN) -- The 49ers head to Tennessee to kick off Week 16. The Titans host San Francisco on Thursday Night Football in an important battle for playoff positioning. Tennessee leads the AFC South at 9-and-5, but has lost three of its past four games. At 8-and-6, the 49ers enter Thursday's matchup as the sixth seed in the NFC. San Francisco is playing great football down the stretch, having won five of its last six games.