Seattle fell 39-32 to the Saints in New Orleans. Geno Smith completed 16 of 25 passes for 268 yards and three touchdowns, including a 40-yard bomb to Tyler Lockett.  DK Metcalf also added 88 receiving yards and a score. The Seahawks are likely losing their starting running back for an extended amount of time.  The NFL Network reports Rashaad Penny suffered a fractured tibia in Seattle's loss to the Saints. The Seahawks will turn to rookie Kenneth Walker III, while Penny is sidelined.

The 49ers rolled to a second straight win after cruising past the Panthers 37-15 in Charlotte.  Jimmy Garoppolo threw for 253 yards and two touchdowns for San Francisco, which leads the NFC West at 3-and-2.