(Portland, OR) -- Oregon health officials are warning about a jump in syphilis cases involving pregnant women. In 2014, Oregon had two cases of congenital syphilis. Last year, that number surged to 45. The number of pregnant women with the disease has increased. It can lead to miscarriage, growth abnormalities, premature birth and fetal death. The Oregon Health Authority recommends pregnant women be tested three times during their pregnancy.